PittsburghV1, Main, Exploration, bibRecord, 001240

Solid-to-fluid–like DNA transition in viruses facilitates infection

Identifieur interne : 001240 ( Main/Exploration ); précédent : 001239; suivant : 001241

Solid-to-fluid–like DNA transition in viruses facilitates infection

Auteurs : Ting Liu ; Udom Sae-Ueng ; Dong Li ; Gabriel C. Lander ; Xiaobing Zuo ; Bengt Jönsson [Suède] ; Donald Rau ; Ivetta Shefer ; Alex Evilevitch [Suède]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.

RBID : PMC:4205597

Descripteurs français

KwdFr :
- ADN viral (), ADN viral (ultrastructure), Bactériophage lambda (), Bactériophage lambda (ultrastructure), Capside (), Cinétique, Cryomicroscopie électronique, Escherichia coli (virologie), Fluorescence, Humains, Maladies virales (virologie), Microscopie à force atomique, Thermodynamique, Transition de phase.
MESH :
- virologie : Escherichia coli, Maladies virales.
- ADN viral, Bactériophage lambda, Capside, Cinétique, Cryomicroscopie électronique, Fluorescence, Humains, Microscopie à force atomique, Thermodynamique, Transition de phase.

English descriptors

KwdEn :
- Bacteriophage lambda (chemistry), Bacteriophage lambda (ultrastructure), Capsid (chemistry), Cryoelectron Microscopy, DNA, Viral (chemistry), DNA, Viral (ultrastructure), Escherichia coli (virology), Fluorescence, Humans, Kinetics, Microscopy, Atomic Force, Phase Transition, Thermodynamics, Virus Diseases (virology).
MESH :
- chemical , chemistry : DNA, Viral.
- chemistry : Bacteriophage lambda, Capsid.
- ultrastructure : Bacteriophage lambda, DNA, Viral.
- virology : Escherichia coli, Virus Diseases.
- Cryoelectron Microscopy, Fluorescence, Humans, Kinetics, Microscopy, Atomic Force, Phase Transition, Thermodynamics.

Abstract

Significance

The efficiency of viral replication is limited by the ability of the virus to eject its genome into a cell. We discovered a fundamentally important mechanism for translocation of viral genomes into cells. For the first time, to our knowledge, we show that tightly packaged DNA in the viral capsid of a bacterial virus (phage λ) undergoes a solid-to-fluid–like structural transition that facilitates infection close to 37 °C. Our finding shows a remarkable physical adaptation of bacterial viruses to the environment of Escherichia coli cells in a human host.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205597

DOI: 10.1073/pnas.1321637111
PubMed: 25271319
PubMed Central: 4205597

Affiliations:

Suède

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>The efficiency of viral replication is limited by the ability of the virus to eject its genome into a cell. We discovered a fundamentally important mechanism for translocation of viral genomes into cells. For the first time, to our knowledge, we show that tightly packaged DNA in the viral capsid of a bacterial virus (phage λ) undergoes a solid-to-fluid–like structural transition that facilitates infection close to 37 °C. Our finding shows a remarkable physical adaptation of bacterial viruses to the environment of <italic>Escherichia coli</italic>
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Solid-to-fluid–like DNA transition in viruses facilitates infection

Solid-to-fluid–like DNA transition in viruses facilitates infection

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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